Reducing the risk and occurrence of infections is the result of an effective infection prevention and epidemiology program. Healthcare informatics and information technology provide a means by which evidence-based care bundles and infection prevention data can be effectively collected, stored, analyzed, and reported from documentation in the electronic healthcare record. The role of technology in infection prevention and control has increased due to regulatory requirements and the desire to secure patient health information. Healthcare informatics is a powerful tool to support infection preventionists to drive high compliance with evidence-based care bundles and in meeting requirements set forth for data availability and public reporting.