People benefit from human-animal interaction socially, psychologically, and physiologically. In healthcare-related situations, programs for animal visitation, animal-assisted activities, animal-assisted therapy, and service animals are intended to assist in returning patients to wellness and independence. Healthcare facilities must establish animal and handler guidelines and program-specific infection prevention policies to provide a safe environment for animals, handlers, and patients. Healthcare providers need to understand and abide by the laws for service animals and persons with disabilities.