Bordetella pertussis (B. pertussis) is a bacterium responsible for the disease commonly known as pertussis, or “whooping cough.” Pertussis is highly communicable and easily transmitted. It is most common among young children and a serious health threat to unvaccinated or under-vaccinated infants. Although vaccines are effective in preventing pertussis, immunity wanes over time. This leaves older children, adolescents, and adults susceptible to infection. If infected, these individuals can be a source of transmission to others. Early antimicrobial treatment of cases and post-exposure prophylaxis of exposed contacts are important for preventing transmission and severe illness. Although rates of pertussis declined during the COVID-19 pandemic, they have since increased. One reason for this increase may be vaccine barriers and reluctance/hesitance. Certain social determinants of health contribute to “immunization inequity,” which results in a disproportionate number of cases and adverse outcomes for vulnerable individuals and populations. New methods for pertussis forecasting, real-time monitoring, and disease prediction may allow for a more proactive response to address barriers, identify trends and outbreaks, and increase global preparedness for infectious disease challenges. Continued efforts are needed to promote vaccine uptake and prevent outbreaks. Infection preventionists (IPs) must be knowledgeable about disease presentation, vaccine recommendations, preventive measures, and outbreak investigation. In addition, providers must understand the importance of early disease detection, prompt treatment of suspected cases, and post-exposure prophylaxis for exposed individuals. A knowledgeable IP can facilitate efforts to increase awareness and promote adherence to recommendations.