In the United States, SSTIs account for 10 percent of all hospital admissions. SSTIs can be community-acquired (CA) or healthcare-associated (HA). Signs and symptoms of SSTIs range in severity from mild (e.g., localized redness and pain) to severe (e.g., abscess, necrotizing fasciitis), and some progress systemically (e.g., fever, sepsis). Staphylococcus aureus and Streptococcus pyogenes, common skin colonizers, are associated with SSTIs. Candida, a common skin commensal, can also cause SSTIs, as well as certain viruses (e.g., herpes simplex viruses [HSV], varicella zoster viruses [VZV]). Treatment depends on the severity of infection and the causative agent. Common treatments are antimicrobials, drainage, and debridement. Prevention measures, such instrument sterility, aseptic technique, hand hygiene, and wound care, play an important role in minimizing the risk of SSTIs.