Over the past few decades, healthcare delivery has experienced a shift from inpatient acute care to a variety of outpatient ambulatory and community care settings ranging from physician offices to ambulatory surgery centers. As this shift becomes more prevalent, the risk of acquiring a healthcare-associated infection (HAI) in the ambulatory care settings also increases. Risk factors associated with this increase are the lack of training and knowledge on infection prevention practices to staff, the type and number of invasive procedures performed, and the advancing age and number of comorbidities among patients. Standard precautions remain the basic approach to the prevention of HAIs across healthcare settings. Careful adherence to infection prevention principles adapted for the outpatient arena will minimize infection risks to patients, healthcare personnel, and family members/visitors. This chapter addresses infection prevention and control (IPC) in ambulatory care settings except ambulatory surgery, dialysis, oncology, dental practices, and endoscopy centers, which are all addressed in other chapters.