Herpes Virus

John Anthony Zaia, MD Professor and Chair, Department of Virology

Beckman Research Institute, City of Hope Medical Center
Duarte, CA

October 2, 2014


The Herpesviridae family is large and found among all vertebrates. The viruses share a common structure and a common biology consisting of a chronic intermittent infection fluctuating between low-level activity (latency) and high-level replication (reactivation). There are eight known herpesviruses of humans, and these form three subfamilies (the alpha-, beta-, and gamma-herpesviruses) that have laboratory and clinical features in common. These characteristics range from rashes to malignancies. The methods for prevention and treatment of these infections are discussed in this chapter.