Herpes Virus

John Anthony Zaia, MD Professor and Chair, Department of Virology

Beckman Research Institute, City of Hope Medical Center
Duarte, CA

Original Publication:
October 2, 2014


The Herpesviridae family is large and found among all vertebrates. The viruses share a common structure and a common biology consisting of a chronic intermittent infection fluctuating between low-level activity (latency) and high-level replication (reactivation). There are eight known herpesviruses of humans, and these form three subfamilies (the alpha-, beta-, and gamma-herpesviruses) that have laboratory and clinical features in common. These characteristics range from rashes to malignancies. The methods for prevention and treatment of these infections are discussed in this chapter.