This chapter covers the etiological agents, epidemiology including outbreaks, surveillance, and isolation guidelines for the patient with burn injury. Clinical sepsis in the burn patient is defined. Specific sites of infection are covered in detail, including clinical manifestation, diagnostic tests, prevention, and treatment. These sites of infection include the burn wound, intravascular catheter-associated infection, suppurative thrombophlebitis, endocarditis, bloodstream infection, urinary tract infection, and pneumonia. Important complications of infection, future trends/research, and international perspectives as they affect the patient with burn injury are also provided.