Dialysis-associated infections include access site infections, bacteremia, peritonitis, and bloodborne pathogens. To prevent these, Infection Preventionists (IPs) need to be familiar with recommendations on reducing the risk of access-associated infections, prevention of bloodborne pathogen transmission, water processing and distribution systems, hemodialyzer reuse, and medication safety. This chapter provides IPs with basic information on the process and risks associated with dialysis and best practices to prevent infections.