Hematopoietic Stem Cell Transplantation

Nedra D. Marion, RN, BSN, MPA, CIC Manager, Department of Infection Control and Epidemiology

The Nebraska Medical Center
Omaha, NE

Kim Schmit-Pokorny, RN, MSN, OCN® Manager

Blood and Marrow Transplantation Program
Oncology/Hematology Division
University of Nebraska Medical Center
Omaha, NE

Dawn Jourdan, RN, BSN Clinical Quality Coordinator

The Nebraska Medical Center
Omaha, NE

Original Publication:
October 2, 2014


Infectious complications remain a limiting factor to hematopoietic stem cell transplantation. Infections are related to a variety of risk factors, including the type of transplant and preparative regimen, the serologic status of the donor and recipient, the presence of graft versus host disease, and numerous environmental factors. Preventive measures should emphasize provision of a protective environment, appropriate use of prophylactic anti-infective agents, and meticulous attention to infection prevention practices, such as hand hygiene, device management, and visitation regulation. After transplantation, immunizations and lifestyle issues should be addressed to minimize late infectious complications.