Vascular access device-associated bloodstream infections (VADA BSI) are largely avoidable. The goal must be prevention rather than simply to identify and treat these infections. During the past two decades, much has been learned about the pathogenesis and epidemiology of infections associated with vascular access devices. As research continues, the efforts made by infection preventionists continue to improve empirical outcomes for the patients they serve. VADA BSI rates are improving due to continuous revision of practice guidelines and recommendations drawing on new evidence-based research.